About Me.
Thomas J. McLellan, M.S. Chemistry, brings over 25 years of experience at Pfizer leading analytical strategies for target characterization, biologics, vaccines, and polymer/ligand analytics. He pioneered walk-up MS systems, developed biomarker quantification workflows, and authored IND/patent documentation for FDA submissions.
Highlighted Projects and Impacts
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Developed Pfizer’s walk-up mass spectrometry system used by 80+ scientists
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Delivered COVID-19 vaccine glycosylation analysis under accelerated timelines
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Collaborated with the Doudna Lab on CRISPR-Cas9 delivery characterization
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Validated biomarker quantification methods critical for translational research
Highlighted Publications
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Silmon de Monerri NC, Che Y, Lees JA, Jasti J, Wu H, Griffor MC, Kodali S, Hawkins JC, Lypowy J, Ponce C, Curley K, Esadze A, Carcamo J, McLellan T, Keeney D, Illenberger A, Matsuka YV, Shanker S, Chorro L, Gribenko AV, Han S, Anderson AS,
Donald RGK. Structure-based design of an immunogenic, conformationally stabilized FimH antigen for a urinary tract infection vaccine. PLoS Pathog. 2025 Feb 19;21(2):e1012325. doi: 10.1371/journal.ppat.1012325. Epub ahead of print. PMID:
39970181. -
Brooke A Conti, Leo Novikov, Deyan Tong, Qing Xiang, Savon Vigil, Thomas J McLellan, Chuong Nguyen, Nancy De La Cruz, Reshma T Veettil, Prashant Pradhan, Parag Sahasrabudhe, Jason D Arroyo, Lei Shang, Benjamin R Sabari, David J Shields,
Mariano Oppikofer (2025) N6-methyladenosine in DNA promotes genome stability eLife 13:RP101626; https://doi.org/10.7554/eLife.101626.3 -
Modjarrad, K., Che, Y., Chen, W. et al. Preclinical characterization of the Omicron XBB.1.5-adapted BNT162b2 COVID-19 vaccine. npj Vaccines 9, 229 (2024). https://doi.org/10.1038/s41541-024-01013-9
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Wei Chen, Kristin R. Tompkins, Ian W. Windsor, Lyndsey T. Martinez, Minah Ramos, Weiqiang Li, Shikha Shrivastava, Swati Rajput, Jeanne S. Chang, Parag Sahasrabudhe, Kimberly F. Fennell, Thomas J. McLellan, Graham M. West, Kristianne P. Dizon, Aaron Yam, Siddartha Mitra, Subrata Saha, Daiana Sharaf, Andrew P. McKeen, Carla I. Cadima, Alexander Muik, Wesley Swanson, Raquel Munoz Moreno, Pilar Mendoza Daroca, Ugur Sahin, Annaliesa S. Anderson, Huixian Wu, Kena A. Swanson, Kayvon Modjarrad Immunologic and Biophysical Features of the BNT162b2 JN.1- and KP.2-Adapted COVID-19 Vaccines, bioRxiv 2024.11.04.621927; doi: https://doi.org/10.1101/2024.11.04.621927
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Rouet, Romain; Thuma, Benjamin A.; Roy, Marc D.; Lintner, Nathanael G.; Rubitski, David M.; Finley, James E.; Wisniewska, Hanna M.; Mendonsa, Rima; Hirsh, Ariana; de Onate, Lorena; Compte Barron, Joan; McLellan, Thomas J.; Bellenger, Justin; Feng, Xidong; Varghese, Alison; Chrunyk, Boris A.; Borzilleri, Kris; Hesp, Kevin D.; Zhou, Kaihong; Ma, Nannan; Tu, Meihua; Dullea, Robert; McClure, Kim F.; Wilson, Ross C.; Liras, Spiros; Mascitti, Vincent; Doudna, Jennifer A.; Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing; J. Am. Chem. Soc. 2018, 140, 6596−6603
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Quantitative Measurement of Potential Biomarkers in Schizophrenia: Analysis of D-Serine, L-Serine and Glycine in Biological Matrices using LC-MS/MS, Thomas J. McLellan, Francis Sweeney, Maria Rosario, Richard O’Sullivan and Holly Soares.
54th ASMS Conference on Mass Spectrometry and Allied Topics. May 28-June 1, 2006, Seattle, Washington.
